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You are receiving this email because you have indicated that you would like to be part the BC Pain Research Network.
Dear BC Pain Research Network members,
Have you found us on Twitter yet? @PainResearchBC
Also, we are very near our goal of having 100 researchers listed in our researcher directory. Please help us reach our goal by joining the network. Surf on over to our website to find out about Network news and upcoming events.
Thank you for your participation.
Table of Contents
Feature Story: Caught in the Crossfire: Patients, Opiates, and the Politics of Pain 
Colloquium by Andrea Tone PhD, Fellow Royal Society of Canada, Professor of History & Canada Research Chair in the Social History of Medicine, McGill University on Monday, December 3 in the Djavad Mowafaghian Centre for Brain Health Rudy North Lecture Theatre (Lower Level 101)
Abstract: No one disputes the gravity of today's opiate epidemic, but how to respond to it has sparked lively debates in the United States and Canada. Should we steeper penalties for dealers? restrict doctors' prescribing power? equip EMS personnel with more antagonist injections?  Often overlooked in these politically charged discussions are the medical needs of patients, especially those who take prescription narcotics.  This talk explores the history and politics of pain management, including the experiences and advocacy of patients in pain.
Biosketch:  Andrea Tone is Professor of History and the Canada Research Chair in the Social History of Medicine. She holds joint appointments in the Faculties of Medicine and Arts at McGill University.  She has published or edited five books, including The Age of Anxiety and Devices and Desires, which inspired the Emmy-award documentary The Pill. In 2011, she received the American Psychiatric Association's Benjamin Rush Prize for outstanding contributions to the history of psychiatry and in 2017 was elected to the Royal Society of Canada.
Network News 
Letter from the Director and Grants Facilitator Drs. Ken Craig and Stacey Herzer
Dear BC Pain Research Network members,
It has been a fantastic year and we have accomplished so many of our goals set out in January. A snapshot shows we have held 10 meet and greet seminars, including one in the Okanagan, with another planned for BC Children’s Hospital; we have brought in 4 distinguished speakers for our colloquium series, as well as Dr. Tone on December 3 (profiled above); we have supported 3 important workshops that are sparking new collaborations and setting the stage for multidisciplinary grant applications to be submitted by next fall; we held our first (and likely annual) BC Pain Research Day which was well attended and showcased so much of the top notch pain research occurring here in BC, and highlighted the need to continue contributing to and improving pain education; and we grew our network to include 96 members currently listed in our researcher directory and are still growing!
We would like to take this opportunity to express our gratitude to each and every one of you. Thank you for all your hard work in helping to make the BC Pain Research Network successful, and advancing the understanding of pain-- hopefully leading to more effective ways to manage, destigmatize, and lessen the burden of living with chronic pain. 
A note from Ken: Time to wish Stacey every success in a new appointment as Manager of Internal Research Competitions in the UBC Vice-president Research and Innovation Office, beginning Dec. 1, 2018.  Our successes this year very much depended upon Stacey’s creativity, people skills and hard work and it will be hard to see her go, but this is an excellent opportunity for her.  Recruiting for a successor begins now (with this message).
Summary of BC Pain Research Network Activities 
Seminars: We held a Network Meet and Greet in Kelowna on October 4 with Dr. Susan Holtzman from UBCO. We had the pleasure to hear introductions from our 13 attending members from diverse backgrounds (patient voice, pain physicians, physiotherapists, graduate students, psychologists, UBC faculty), followed by a description of the network, its resources and activities, and ways to connect and support clinicians and researchers practicing in BC’s Interior. Other topics covered included: current pain research being conducted on UBC campus and in the community, the state of affairs regarding funding opportunities for pain research, health authority funding for a pain clinic, how in contradiction to Ministry requirements there is little funding available to some of the health authorities to fund pain clinics (what can we do about this?), the state of affairs regarding services available for those with chronic pain (medical and psychosocial) in the Okanagan – limited, long waitlists, possibility of collaboration between community pain services and UBC inter-professional clinic. We closed out the session with a discussion of research topics with strong interest including (but not limited to):  "big data" for pain research (creating large, centralized databases/registries of people with pain), using technology to monitor and treat pain (e.g., smartphone applications to track daily pain), and cannabis for chronic pain.
Colloquia: Together with the Re-Imagine Aging research cluster we co-hosted Prof. Thomas Hadjistavropoulos, Research Chair in Aging and Health and Registered Doctoral Psychologist at the University of Regina on October 19. His colloquium titled "Pain Assessment in Older Persons with Dementia" drew an audience from neuroscience, the animal welfare program, psychology, nursing, and caregivers. He spoke about evidence-based behavioural assessment of pain in dementia, tools to measure this including the Pain Assessment Checklist for Seniors with Limited Ability to Communicate (PACSLAC), and his recent work toward the development of automated pain assessment methods using computer vision technologies.
Workshops: The Pain and Nonverbal Self-report Workshop was held on Oct 24 at The Peter Wall Institute for Advanced Studies. We had the pleasure of hearing from Rebeccah Slater (Oxford):  The measurement and treatment of pain in infants, Fiona Moultrie (Oxford):  The development of pain perception in early life, David Edelman (Dartmouth):  Assessment of Pain in Non-Human Animals: What Can It Tell Us About the Human Case, Frank Symons and Alyssa Merbler (U of Minnesota):  Non-verbal approaches to assessing pain in people with neurodevelopmental disabilities. This workshop drew an audience of over 30 people including clinicians and researchers studying pediatrics, ethics, and animal welfare. Sophisticated brain imaging and EEG recordings during noxious and non-noxious stimuli in preterm and term infants were discussed as tools to try and learn about pain processing and pain experience in nonverbal populations, as well as behavior studies in octopuses and dairy cows and how they might inform research and pain evaluation in humans.  
The Pain, Affect, and Opioids Workshop was held on Nov 9 at UBC Robson Theater. Adam Shriver (Oxford) spoke about ethical and philosophical ideas of pain perception and management, and how we might decrease the unpleasantness of pain. David Silver (UBC) discussed a brief literature review of why pain is “bad”, and came up with two main themes: 1. because it hurts and 2. we do not like it. He then refuted these reasons based on the dolorist view of “hurts so good” (e.g. why some people like the burning and stinging from hot sauce). He posited that pain is bad not because of how it feels or its unpleasantness, but when it undermines our autonomy and requires so much of our attention that we feel we cannot escape, that we have lost agency over our bodies, and cannot engage in social behaviours. Greg Corder (U Penn) spoke about pain being conserved across species to shape behaviour, and how damage to a brain region called the posterior insula may lessen the unpleasantness of pain. He discussed how Bayesian perception represents reality in a useful way to shape our behaviours, but our brains do not create exact representations of our environment, and perhaps this can be manipulated either electrically or pharmacologically to lessen negative valence or suffering from pain. Mark Sullivan (U Washington) described pain as existing more to protect and warn us of potential serious damage than to inform us that damage has occurred, and that in humans our social survival is as important as physical survival, and the two are closely linked. He discussed that to help chronic pain patients, clinicians can arm them with purposive action to alter the salience of their pain experience. By getting patients to change behaviour and increase their movement and action, they may hurt less. Howard Fields (UCSF) discussed his Motivation-Decision model of pain where the context of the situation can allow a top down modulation of the pain signal in a bidirectional way such that if a great reward is expected, then endogenous opioids can be released to dampen the pain response; but if a greater threat is predicted, then the pain signal is permitted or intensified by descending facilitation of activity in the dorsal horn neurons, initiating escape behaviour. He suggests that reward refines the biological benefit of pain. The workshop ended with a panel discussion and suggestions for future collaborations.
BC Pain Research Day: We held our BC Pain Research Day on October 22. The successful event showcased 28 posters, featured a keynote by Debra Gordon from University of Washington on pain education, and raised awareness of pain research happening at UBC, spanning biomedical and clinical pain research to social, cultural, population health pain research, and pain educational programs and resources offered by Pain BC. We had 52 people attend, including senior researchers, clinicians, trainees, staff, members of Pain BC, consultants, and a senior policy analyst from the Ministry of Health who is working on the draft provincial pain strategy to be rolled out in 2019. We would like to congratulate our 4 poster winners for their excellent effort and commend all those who participated in the talks and poster presentations. For the category of biomedical pain research, Desmond Fung won for his poster titled “Long-lasting sensory blockade produced by quaternary lidocaine derivatives: an in vivo efficacy and safety study in mice”. For the category of clinical pain research Kate Wahl won for her poster titled “Pelvic pain and infertility concerns among women with endometriosis”. For the category of social, cultural, population health pain research Katelynn Boerner won for her poster titled Relationship Between Stage of Behavior Change and Functioning in Youth with Somatization”. For the category of health services delivery, Rachel Benjamin won for her poster titled “National Indicators of Uncertainty Predict Purchases of Over-the-Counter Painkiller Drugs”. We hope to make this an annual event and look forward to your participation in fall 2019!
Upcoming Events 
Seminars: Nicholas Vasilis Karayannis, MPT, PhD from Stanford Medicine Pain Management Center will be giving a seminar titled “A Physical and Behavioral Integrative Therapies for People with Chronic Spinal Pain” on Nov. 27 in the Centre for Brain Health, Lecture Theatre 101, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3.
Bio: Dr. Nicholas Karayannis (Pronounced KA-ruh-YAH-nees) is a postdoctoral research fellow in Interdisciplinary Pain Medicine at Stanford University School of Medicine. Nicholas is also a Senior Physical Therapist within the Stanford Pain Management Center and Orthopaedic and Sports Medicine Clinic. He has practiced within the outpatient orthopaedic physical therapy setting for over 18 years. His mission as a pain specialist physiotherapist and clinical scientist is to further the practice and integration of mindfulness, both in the lives of individuals living with chronic musculoskeletal pain and in society through health care and research. Nicholas’s career goal is to better understand the processes and mechanisms of mindfulness-based interventions (MBIs) for people with chronic musculoskeletal pain through the behavioral investigation of meditation, motivation, and movement theory-informed practice.
The next BCPRN Meet and Greet will be held at BC Children’s Hospital in early December. Please check the events calendar for updates and details.  
Webinars: BCPRN member Dr Alex Scott will give a Pain BC webinar on Dec 13, 2018 at 12:00 pm PST titled “Contemporary Treatment Approaches for Chronic Tendon Pain”. Many treatments have been recommended for the treatment of chronic tendon pain (tendinopathy). The diversity of possible treatments can challenge patients and their treatment providers. This webinar will take an evidence-informed approach while presenting a contemporary understanding of chronic tendon pain and the best supported approaches to manage it. The results of a recently completed placebo-controlled trial for knee tendon pain will also be presented.
Workshops: Vancouver Coastal Health Research Stakeholder Workshop Friday, December 7, 2018 10:00am-12:00pm at Vancouver General Hospital
On behalf of the BC SUPPORT Unit Patient-Centred Measurement Methods Cluster (PCM) leads, Dr. Rick Sawatzky, Canada Research Chair in Person-Centred Outcomes and Lena Cuthbertson, Provincial Executive Director of Patient-Centered Measurement & Improvement, you are invited to attend a 2-hour workshop on Friday, December 7th, from 10:00am-12:00pm at Vancouver General Hospital.
The PCM Methods Cluster invites Vancouver Coastal Health researchers and trainees, clinicians, and health system decision makers who utilize knowledge generated through Patient Reported Experience Measures (PREMS) and Patient Reported Outcome Measures (PROMS), to provide input on methodological priorities for patient-centred measurement that will inform the PCM Methods Cluster call for research proposals.
Interested in participating?
Please RSVP to Serena Bertoli-Haley, Quality Improvement and Patient Experience Leader:
Phone or Text: 604 785 2669
(Please include “RSVP” in subject line)
Funding Opportunities 
CIHR has launched an online linkage tool designed to assist researchers and other stakeholders in identifying and connecting with potential partners to develop their projects.
Registration Deadline: Feb 6, 2019
Application Deadline    Mar 6, 2019
Spring 2019 Priority Announcement (Specific Research Areas) - to be announced
  • $7,000 to $25,000 for events, and up to $50,000 for other outreach activities; higher amounts for outreach activities may be considered if well justified
  • Application Deadlines (4 cycles/year): Feb 1, 2019
  • Connection Grants support workshops, colloquiums, conferences, forums, summer institutes, or other events or outreach activities that facilitate:
  • disciplinary and/or interdisciplinary exchanges in the humanities and social sciences;
  • scholarly exchanges between those working in the social sciences and humanities and those working in other research fields;
  • intersectoral exchanges between academic researchers in the humanities and social sciences and researchers and practitioners from the public, private and/or not-for-profit sectors; and/or
  • international research collaboration and scholarly exchanges with researchers, students and non-academic partners from other countries.
  • $25,000 for 6 months. At minimum, an in-kind contribution from the company reflecting its active involvement in the project is required
  • Support a new research collaboration with an industrial partner through a short-term research and development (R&D) project that applies their expertise to address a company challenge.
  • Rolling deadline
  • The GGI program is specifically designed to promote and enhance Canada’s international innovation efforts. The program supports researchers who aim to commercialize technology by pursuing collaborative international research and development (R&D) opportunities through partnerships with key players in foreign markets. Eligible beneficiaries are Canadian innovators from small or medium size enterprises, universities and nongovernment research centres.
  • GGI provides assistance by contributing up to 75% of eligible expenses, up to a maximum of $75,000 for any approved project. Eligible expenses may include international and local travel, accommodation, meals, meeting costs, legal fees to support formalized partnerships, and other costs related to international collaboration.
  • Application Deadline: Continuous.
Other Canadian Funding competitions:
UBC-V: CFI Innovation Fund – Expression of Interest
Faculty on the Vancouver campus are invited to submit an internal EOI for the Canada Foundation for Innovation’s (CFI) Innovation Fund by Jan. 11, 2019.
  • As part of the HEAL (Helping to End Addiction Long-term) Initiative, NIH will support research on how chronic pain develops and on new treatments to alleviate chronic pain.  HEAL will develop a data sharing collaborative, new biomarkers for pain, and a clinical trials network for testing new pain therapies
  • Notices of Intent to Publish FOAs for a Clinical Trials Network on Pain Research
  • The Rita Allen Foundation (RAF) and American Pain Society (APS) announce the 2019 Award in Pain. The RAF and APS may award two grants in the amount of $50,000 annually, for a period of up to three years to those research proposals demonstrating the greatest merit and potential for success.
  • Application due date: Dec 17, 2018
American Orthopaedic Society for Sports Medicine: Osteoarthritis Basic Science Research Grant
  • Supports either a clinical research study or a lab/basic science project in the areas of early osteoarthritis and/or the prevention of OA progression
  • $50,000 for 1 year
  • Due Jan 1, 2019
  • The FOA is expected to be published in December 2018, with an expected application due date in February 2019. Please see NOT-TR-19-007 for more information.
  • The purpose of this Small Business Innovation Research (SBIR) Funding Opportunity Announcement (FOA) is to develop a technology/device that objectively indicates the presence and level of pain.
  • Cycle II: January 5, 2019
  • Cycle III: April 5, 2019
  • Seeks small business organizations to develop opioid and adjuvant drug combinations within a single dosage form for treatment of a pain condition.
  • Cycle II: January 5, 2019
  • Cycle III: April 5, 2019
  • Encourages research that investigates the role of epigenetic or non-coding RNA regulatory pathways in the development, maintenance, or treatment of chronic pain. Ultimately research in the area will provide foundational knowledge that can be exploited to develop novel and non-addictive pain medications or to develop biomarkers that predict chronic pain progression or treatment response.
  • LOI due Jan 11, 2019; Application due date: Feb 11, 2019
  • Cycle I due date Jan 25, 2019
  • Supports early phase clinical trials of mind and body approaches for conditions that have been identified by NCCAM as high priority research topics.
  • Seeks to address two specific mechanistic pathways via which psychosocial stress may modulate opioid use trajectories.
    • The first pathway is through its effects on cognitive and affective systems that are also altered in OUDs.
    • Second related pathway is substantial co-morbidity between OUD and stress-related affective disorders, including depression, anxiety and PTSD.
  • Cycle I due date: January 25, 2019
PA-18-376, PA-14-474, PA-14-384: Self-Management for Health in Chronic Conditions (R01, R15, R21)
  • Cycle I due date: January 25, 2019
PPA-15-141, PA-15-142, PA-15-143: International Research Collaborations on Drug Abuse and Addiction Research (R03, R01, R21)
  • Cycle I due date: January 25, 2019
  • Supports innovative research that will elucidate the mechanisms underlying migraine; expand our current knowledge of the role of genetic, physiological, biopsychosocial, and environmental influences in migraine susceptibility and progression; and explore new therapeutic targets and therapies for acute migraine management and longer-term prevention.
  • Cycle I due date: January 25, 2019
  • Promotes preclinical, translational, clinical and epidemiological research in pain medications use in children or in pregnant women to fill knowledge gaps in safe use of the pain medications in these special populations
  • Develops effective instruments or approaches to assess and evaluate maternal and child outcomes of pain medication treatments
  • Budgets are not limited but need to reflect the actual needs of the proposed project
  • Maximum of 5 years
  • Cycle I due date: January 25, 2019
  • The purpose of the Funding Opportunity Announcement is to encourage grant applications from the scientific community on the biobehavioral basis of chronic pain. The focus encompasses the individual phenotype, genotype, and other omic-type assessments and the associated sensory and emotional components that underpin the individual’s chronic pain experience.
  • Cycle I due date: February 5, 2019
  • The purpose of this Funding Opportunity Announcement (FOA) is to encourage epidemiological, clinical and translational research that will increase our understanding of the natural history, prevalence, biological mechanisms, psychological variables, and clinical risk factors responsible for the presence of multiple chronic pain conditions in people with pain.
  • Cycle I due date: February 5, 2019
  • Purpose is to promote the discovery of strong candidate biomarkers and endpoints for pain that can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials.  Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical validation of pain biomarkers, biomarker signatures, and/or endpoints. Although research supported by this FOA can include animal studies, it must also include preliminary human validation using carefully standardized human samples or human clinical studies. The goal of this initiative is to deliver candidate biomarkers, biomarker signatures, and/or endpoints that are ready for advanced clinical and analytical validation research.
  • Letter of Intent due Feb 7; Application due Mar 7 2019
  • The purpose of the Funding Opportunity announcement is to encourage grant applications from the scientific community on applying a biopsychosocial perspective to self-management of chronic pain.
  • The first standard application due date for this FOA is February 16, 2019.
  • This funding opportunity announcement (FOA) invites innovative research to characterize the consequences of psychosocial stress on affective/cognitive functioning and/or pain processing as it relates to opioid use disorder (OUD).
  • LOI due Jan 16, 2019; Application due Feb 16, 2019
  • The purpose of the Funding Opportunity Announcement is to encourage grant applications from the scientific community on the biobehavioral basis of chronic pain.  The focus encompasses the individual phenotype, genotype, and other omic-type assessments and the associated sensory and emotional components that underpin the individual’s chronic pain experience. Research relating biology and behavior is needed to better define the individual-specific burden of chronic pain and to better understand the mechanisms underlying differences in pain experiences among individuals afflicted with the same chronic illness.
  • The first standard application due date for this FOA is February 16, 2019.
  • OnPAR is a Private Business Venture that partners with international agencies to provide ‘second-chance’ funding opportunities to high-scoring applications in biomedical fields. Several pharmaceuticals and biotech companies and other private biomedical agencies have joined OnPAR.
  • See the full list of partners here. OnPAR accepts abstracts from CIHR.
  • See the current list of Funding Members to get an idea of what they might be looking for. OnPAR is working to add additional Members.
  • There is no need to re-write your grant proposal. Once you submit your abstract and peer review scores, all abstracts are available for Funding Members to review. Applications and Summary Statement submission is by invitation only. OnPAR will accept the original abstract and the summary statement or review evaluations that you received from NIH or the reviewing organization.
  • Proposals that meet the criteria are accepted: 30th percentile for major disease areas, (i.e., Cancer, Alzheimer’s, Parkinson’s, Diabetes); 50th percentile for rare disease areas; promising non-percentiled)
  • OnPar has now expanded to include pain research projects.

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