WINTER 2019 NEWSLETTER
 
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     Past Events                      Important News   
2018 SebastianStrong 5K Run/Walk
November 10, 2018
This year's 5K was even more amazing than last year's. It is so uplifting to see so many supporters come out early on a Saturday morning to raise awareness for this terrible disease. Thanks to the hard work & support of so many, participants got to enjoy live music, face painting, arts & crafts, food trucks, & more. To view pictures of the morning please visit:

2018 SebastianStrong Gala
November 10, 2018 
The 2018 Gala was a great success. A big thanks to our sponsors and all who attended, donated items to our silent auction, or volunteered. The food was delicious & the music superb - thank you PALO!. The addition of a live painting by artist Chiara Mecozzi was a great experience. To view pictures from the evening please visit: 
 
      ~Farah Guzman with Rose & Oscar Ortiz~
 
 SAVE THE DATE
November 9, 2019
3rd Annual Childhood Cancer Awareness Weekend
5K Run/Walk & Gala
Holiday Hospital & Clinic Visits
December 2018 
Thanks to the generosity & support of 2 local high schools, SebastianStrong was able to sponsor two holiday parties - one at a local children's oncology clinic and the other on the oncology floor of the public hospital. The children & parents participated in art activities and all the children (including siblings) got to take home some really amazing toys and gifts. A HUGE thank you to the students, parents, & faculty of Belen Jesuit Preparatory School and Christopher Columbus High School.
 
  
2018 SPONSORS
 
 
 
Continuing Education
SebastianStrong Board of Directors
A critical role for the Board of Directors of SebastianStrong Foundation is to determine how to most effectively utilize your donations. To this end, Board members work hard to stay abreast of the latest developments and trends related to pediatric cancer research.
 
In November, as part of SebastianStrong’s 2nd Annual Childhood Cancer Awareness Weekend, the Board spent a day at the University of Miami’s Sylvester Comprehensive Cancer Center, listening to leading cancer researchers explain advances in research and touring the labs and Clinic that treats children at the Hospital. Jim McAllister, Chair of the Medical Advisory Board, described the experience as follows, “Dr. Matteo Trucco’s team gave us an intensive education on the latest developments in cancer research and made certain that Board members saw first-hand the efforts being made to find less toxic cures for pediatric cancers. This helps Board members understand the recommendations from the doctors on the Medical Advisory Board, allowing us to be judicious and impactful with all donations.”
 
In January, Rose & Oscar Ortiz attended the 2019 MIB Factor Conference for pediatric osteosarcoma. They had the opportunity to listen to and meet leading researchers in the field who shared updates on the various ways that the pediatric cancer community is working to offer children in the fight better options.
 
In February, Jim McAllister & Rose Ortiz will be heading to the National Pediatric Cancer Foundation's Annual Research Summit, along with all three of our Medical Advisory Board doctors - Dr. David Loeb, Dr. Ginna Priola, & Dr. Matteo Trucco. Here the nation’s leading pediatric cancer researchers will present groundbreaking information about new research projects & clinical trials aimed at treating & curing pediatric cancer. Additionally, this will be the first "in-person" meeting of SebastianStrong's Medical Advisory Board & we are so excited to see what arises from this brainstorming session.
 
SebastianStrong-Funded Research Updates 
Dr. Michael Leibowitz, Children's Hospital of
Philadelphia
 “With the support of SebastianStrong Foundation, I was able to hire a technician in the lab, which has been very helpful in advancing our project. We are currently performing in vivo mouse experiments to determine whether modification of our CAR T cells to secrete FLT3 ligand enhances killing of solid tumors through epitope spreading. I am excited to see what the data will show.”
 
Dr. Jeffrey Rubens, Johns Hopkins University
“We continue to be very excited about the progress we have made in our SebastianStrong Foundation funded research. We continue to develop the pre-clinical data that will support a future clinical trial aimed at improving survival in atypical teratoid rhabdoid tumors (AT/RT). We have found that the glutamine metabolic inhibitor, 6-diazo-5- oxo-L-norleucine (DON) combines synergistically with carboplatin to extend survival in orthotopic mouse models of AT/RT. We aim to submit our findings for publication this month, & continue to work toward developing the first clinical trial utilizing DON therapy to target aggressive, MYC- expressing tumors.”
 
Dr. Matteo Trucco, Universirty of Miami SCCC
“With the support of the SebastianStrong Foundation combined with support from similar foundations, we secured the funding necessary to conduct a clinical trial testing the ability of a drug called disulfiram (Antabuse) to overcome the resistance to chemotherapy seen in several sarcomas. Disulfiram blocks an enzyme called Aldehyde Dehydrogenase. This enzyme has been found to make cancer cells resistant to many of the chemotherapy drugs used to treat pediatric sarcomas. By blocking this enzyme, we hope to make chemotherapy more effective in treating those cancers, and in time potentially enable doses to be reduced leading to less toxic treatments. With all the necessary funding secured, we are in the process of obtaining approval by the University and the FDA to conduct the trial and contract with laboratories to perform the drug and enzyme measurements necessary to assure we are hitting the target.” 
 
On-Line Merchandise Store
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Address postal inquiries to:
SebastianStrong Foundation
P.O. BOX 661156
Miami Springs, FL 33266

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